Many thermoplastic parts are exposed to environmental conditions which can lead to premature field failures. One of the most difficult of these considerations to address in the material selection process is exposure to aggressive chemicals. Ketoprix polyketone offers designers and engineers a solution to this challenge as it exhibits very broad chemical resistance rivaling that of exotic resins such as PVDF without their high costs. This article provides an overview of the chemical resistance of Ketoprix polyketone in addition to some guidelines to help engineers and designers navigate this part of the material selection process successfully.